教員情報

衣斐 大祐
イビ ダイスケ
薬学部 薬学科
准教授
Last Updated :2019/06/04

基本情報

プロフィール

    男性

現在所属している学会

  • 日本薬理学会
  • 日本神経科学会
  • 日本神経化学会
  • 日本神経精神薬理学会
  • 日本薬学会
  • 北米神経科学会

研究活動

研究分野

  • 神経化学・神経薬理学

学術論文

  • Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3.
    Yamada S, Itoh N, Nagai T, Nakai T, Ibi D, Nakajima A, Nabeshima T, Yamada K
    Journal of neuroinflammation
    15, 1, 295
    2018年10月
  • Effect of AceK (acesulfame potassium) on brain function under dietary restriction in mice
    共著
    Physiology & Behavior
    188, 291, 297
    2018年05月
  • Effect of AceK (acesulfame potassium) on brain function under dietary restriction in mice.
    D Ibi, F Suzuki, M Hiramatsu.
    Physiology & Behavior
    188, 123
    2018年05月
  • MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice
    共著
    Amanda C. Mitchell, Behnam Javidfar, Venu Pothula, Daisuke Ibi, Erica Y. Shen, Cyril J. Peter, Lucy Bicks, Tristan Fehr, Yan Jiang, Kristen J. Brennand, Rachael L. Neve, Javier Gonzalez-Maeso, Schahram Akbarian
    Molecular Psychiatry
    23, 1, 123, 132
    2018年
  • MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice.
    AC Mitchell, B Javidfar, V Pothula, D Ibi, EY Shen, CJ Peter, L Bicks, T Fehr, Y Jiang, KJ Brennand, RL Neve, J Gonzalez-Maeso, S Akbarian.
    Molecular Psychiatry
    23, 123
    2018年
  • MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice.
    AC Mitchell, B Javidfar, V Pothula, D Ibi, EY Shen, CJ Peter, L Bicks, T Fehr, Y Jiang, KJ Brennand, RL Neve, J Gonzalez-Maeso, S Akbarian.
    Molecular Psychiatry
    23, 123
    2018年
  • Antipsychotic-induced Hdac2 transcription via NF-kB leads to synaptic and cognitive side effects
    共著
    (1) Ibi D, de la Fuente Revenga M, Kezunovic N, Muguruza C, Saunders JM, Gaitonde SA, Moreno JL, Ijaz MK, Santosh V, Kozlenkov A, Holloway T, Seto J, García-Bea A, Kurita M, Mosley GE, Jiang Y, Christoffel DJ, Callado LF, Russo SJ, Dracheva S, López-Giménez JF, Ge Y, Escalante CR, Meana JJ, Akbarian S, Huntley GW, González-Maeso J.
    Nature Neuroscience
    20, 1247, 1259
    2017年09月
  • Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive side effects.
    Ibi D, de la Fuente Revenga M, Kezunovic N, Muguruza C, Saunders JM, Gaitonde SA, Moreno JL, Ijaz MK, Santosh V, Kozlenkov A, Holloway T, Seto J, García-Bea A, Kurita M, Mosley GE, Jiang Y, Christoffel DJ, Callado LF, Russo SJ, Dracheva S, López-Giménez JF, Ge Y, Escalante CR, Meana JJ, Akbarian S, Huntley GW, González-Maeso J
    Nature neuroscience
    20, 9, 1247
    2017年09月
  • Therapeutic Targets for Neurodevelopmental Disorders Emerging from Animal Models with Perinatal Immune Activation.
    共著
    Ibi D, Yamada K
    Int J Mol Sci
    16, 12, 28218, 28229
    2015年11月
  • Therapeutic Targets for Neurodevelopmental Disorders Emerging from Animal Models with Perinatal Immune Activation.
    D Ibi, K Yamada.
    International Journal of Molecular Sciences
    16, 12, 28218
    2015年11月
  • Therapeutic Targets for Neurodevelopmental Disorders Emerging from Animal Models with Perinatal Immune Activation.
    D Ibi, K Yamada.
    International Journal of Molecular Sciences
    16, 12, 28218
    2015年11月
  • Epigenetic signaling in schizophrenia.
    共著
    Ibi D, Gonzalez-Maeso J
    Cell Signal
    5, 2131, 2136
    2015年10月
  • Epigenetic signaling in schizophrenia.
    D Ibi, J Gonzalez-Maeso
    Cellular Signalling
    5, 10, 2131
    2015年10月
  • FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization.
    Udagawa T, Fujioka Y, Tanaka M, Honda D, Yokoi S, Riku Y, Ibi D, Nagai T, Yamada K, Watanabe H, Katsuno M, Inada T, Ohno K, Sokabe M, Okado H, Ishigaki S, Sobue G
    Nature communications
    6, 7098
    2015年05月
  • FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization
    共著
    Udagawa T, Fujioka Y, Tanaka M, Honda D, Yokoi S, Riku Y, Ibi D, Nagai T, Yamada K, Watanabe H, Katsuno M, Inada T, Ohno K, Sokabe M, Okado H, Ishigaki S, Sobue G.
    Nat Commun
    7098
    2015年03月
  • Induction of interferon-induced transmembrane protein 3 gene expression by lipopolysaccharide in astrocytes
    共著
    Nakajima A, Ibi D, Nagai T, Yamada S, Nabeshima T, Yamada K
    Eur J Pharmacol
    15, 745, 166, 175
    2014年12月
  • Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes
    S Yamada, T Nagai, T Nakai, D Ibi, A Nakajima, K Yamada.
    Brain, Behavior, and Immunity
    38, 272
    2014年05月
  • Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes.
    共著
    Yamada S, Nagai T, Nakai T, Ibi D, Nakajima A, Yamada K.
    Brain Behav Immun
    272, 282, 272, 282
    2014年03月
  • SHATI/NAT8L regulates neurite outgrowth via microtubule stabilization.
    共著
    Toriumi K, Ikami M, Kondo M, Mouri A, Koseki T, Ibi D, Furukawa-Hibi Y, Nagai T, Mamiya T, Nitta A, Yamada K, Nabeshima T
    J Neurosci Res
    91, 19, 1525, 1532
    2013年12月
  • SHATI/NAT8L regulates neurite outgrowth via microtubule stabilization.
    Toriumi K, Ikami M, Kondo M, Mouri A, Koseki T, Ibi D, Furukawa-Hibi Y, Nagai T, Mamiya T, Nitta A, Yamada K, Nabeshima T
    Journal of neuroscience research
    91, 12, 1525
    2013年12月
  • Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice.
    D Ibi, T Nagai, A Nakajima, H Mizoguchi, T Kawase, D Tsuboi, S Kano, Y Sato, M Hayakawa, UC Lange, DJ Adams, MA Surani, T Satoh, A Sawa, K Kaibuchi, T Nabeshima, K Yamada.
    GLIA
    61, 5, 679
    2013年05月
  • Animal models of schizophrenia for molecular and pharmacological intervention and potential candidate molecules.
    Mouri A, Nagai T, Ibi D, Yamada K
    Neurobiology of disease
    53, 61
    2013年05月
  • Animal models of schizophrenia for molecular and pharmacological intervention and potential candidate molecules.
    共著
    Mouri A, Nagai T, Ibi D, Yamada K.
    Neurobiol Dis
    53, 61, 74
    2013年03月
  • Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice.
    共著
    Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T, Tsuboi D, Kano S, Sato Y, Hayakawa M, Lange UC, Adams DJ, Surani MA, Satoh T, Sawa A, Kaibuchi K, Nabeshima T, Yamada K
    Glia
    61, 5, 679, 693
    2013年03月
  • Effects of sub-acute and sub-chronic inhalation of 1-bromopropane on neurogenesis in adult rats.
    共著
    Zhang L, Nagai T, Yamada K, Ibi D, Ichihara S, Subramanian K, Huang Z, Mohideen SS, Naito H, Ichihara G.
    Toxicology
    8, 304, 76, 82
    2013年02月
  • Effects of sub-acute and sub-chronic inhalation of 1-bromopropane on neurogenesis in adult rats.
    Zhang L, Nagai T, Yamada K, Ibi D, Ichihara S, Subramanian K, Huang Z, Mohideen SS, Naito H, Ichihara G
    Toxicology
    304, 76
    2013年02月
  • Placental extract improves hippocampal neuronal loss and fear memory impairment resulting from chronic restraint stress in ovariectomized mice.
    共著
    Takuma K, Mizoguchi H, Funatsu Y, Kitahara Y, Ibi D, Kamei H, Matsuda T, Koike K, Inoue M, Nagai T, Yamada K
    J Pharmacol Sci
    120, 2, 89, 97
    2012年09月
  • Functional analysis of stress-responsible transcription factor Npas4 in stress-induced brain dysfunction.
    共著
    Nagai T, Yun J, Ibi D, Koike H, Hibi Y, Yamada K
    日本薬理学雑誌
    139, 4, 147, 151
    2012年04月
  • [Functional analysis of stress-responsible transcription factor Npas4 in stress-induced brain dysfunction].
    Nagai T, Yun J, Ibi D, Koike H, Hibi Y, Yamada K
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica
    139, 4, 147
    2012年04月
  • Placental extract improves hippocampal neuronal loss and fear memory impairment resulting from chronic restraint stress in ovariectomized mice.
    Takuma K, Mizoguchi H, Funatsu Y, Kitahara Y, Ibi D, Kamei H, Matsuda T, Koike K, Inoue M, Nagai T, Yamada K
    Journal of pharmacological sciences
    120, 2, 89
    2012年
  • Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse
    共著
    Kuroda K, Yamada S, Tanaka M, Iizuka M, Yano H, Mori D, Tsuboi D, Nishioka T, Namba T, Iizuka Y, Kubota S, Nagai T, Ibi D, Wang R, Enomoto A, Isotani-Sakakibara M, Asai N, Kimura K, Kiyonari H, Abe T, Mizoguchi A, Sokabe M, Takahashi M, Yamada K, Kaibuchi K
    Hum Mol Genet
    20, 23, 4666, 4683
    2011年12月
  • Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.
    Kuroda K, Yamada S, Tanaka M, Iizuka M, Yano H, Mori D, Tsuboi D, Nishioka T, Namba T, Iizuka Y, Kubota S, Nagai T, Ibi D, Wang R, Enomoto A, Isotani-Sakakibara M, Asai N, Kimura K, Kiyonari H, Abe T, Mizoguchi A, Sokabe M, Takahashi M, Yamada K, Kaibuchi K
    Human molecular genetics
    20, 23, 4666
    2011年12月
  • PolyI:C-induced neurodevelopmental animal model for schizophrenia
    共著
    Ibi D, Nagai T, Nabeshima T, Yamada K
    日本薬理学雑誌
    31, 5, 201, 207
    2011年11月
  • Effects of antipsychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal polyI:C treatment.
    共著
    Nagai T, Kitahara Y, Ibi D, Nabeshima T, Sawa A, Yamada K
    Behav Brain Res
    225, 1, 305, 310
    2011年11月
  • [PolyI:C-induced neurodevelopmental animal model for schizophrenia].
    Ibi D, Nagai T, Nabeshima T, Yamada K
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology
    31, 5-6, 201
    2011年11月
  • Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus.
    共著
    Mizoguchi H, Nakade J, Tachibana M, Ibi D, Someya E, Koike H, Kamei H, Nabeshima T, Itohara S, Takuma K, Sawada M, Sato J, Yamada K
    J Neurosci
    31, 36, 12963, 12971
    2011年09月
  • The hydrophobic dipeptide Leu-Ile inhibits immobility induced by repeated forced swimming via the induction of BDNF.
    共著
    Furukawa-Hibi Y, Nitta A, Ikeda T, Morishita K, Liu W, Ibi D, Alkam T, Nabeshima T, Yamada K.
    Behav Brain Res
    220, 2, 271, 280
    2011年07月
  • Nicotine ameliorates impairment of working memory in methamphetamine-treated rats.
    共著
    Mizoguchi H, Ibi D, Takase F, Nagai T, Kamei H, Toth E, Sato J, Takuma K, Yamada K
    Behav Brain Res
    220, 1, 159, 163
    2011年06月
  • Animal model for schizophrenia that reflects gene-environment interactions.
    共著
    Nagai T, Ibi D, Yamada K
    Biol Pharm Bull
    1364, 1368
    2011年
  • Animal model for schizophrenia that reflects gene-environment interactions.
    Nagai T, Ibi D, Yamada K
    Biological & pharmaceutical bulletin
    34, 9, 1364
    2011年
  • RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction.
    Takuma K, Fang F, Zhang W, Yan S, Fukuzaki E, Du H, Sosunov A, McKhann G, Funatsu Y, Nakamichi N, Nagai T, Mizoguchi H, Ibi D, Hori O, Ogawa S, Stern DM, Yamada K, Yan SS
    Proceedings of the National Academy of Sciences of the United States of America
    106, 47, 20021
    2009年11月
  • Matrix metalloprotease-9 inhibition improves amyloid beta-mediated cognitive impairment and neurotoxicity in mice.
    Mizoguchi H, Takuma K, Fukuzaki E, Ibi D, Someya E, Akazawa KH, Alkam T, Tsunekawa H, Mouri A, Noda Y, Nabeshima T, Yamada K
    The Journal of pharmacology and experimental therapeutics
    331, 1, 14
    2009年10月
  • Behavioral abnormality and pharmacologic response in social isolation-reared mice.
    Koike H, Ibi D, Mizoguchi H, Nagai T, Nitta A, Takuma K, Nabeshima T, Yoneda Y, Yamada K
    Behavioural brain research
    202, 1, 114
    2009年08月
  • Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood.
    Ibi D, Nagai T, Kitahara Y, Mizoguchi H, Koike H, Shiraki A, Takuma K, Kamei H, Noda Y, Nitta A, Nabeshima T, Yoneda Y, Yamada K
    Neuroscience research
    64, 3, 297
    2009年07月
  • GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice.
    Arai S, Takuma K, Mizoguchi H, Ibi D, Nagai T, Kamei H, Kim HC, Yamada K
    European journal of pharmacology
    602, 1, 101
    2009年01月
  • Involvement of pallidotegmental neurons in methamphetamine- and MK-801-induced impairment of prepulse inhibition of the acoustic startle reflex in mice: reversal by GABAB receptor agonist baclofen.
    Arai S, Takuma K, Mizoguchi H, Ibi D, Nagai T, Takahashi K, Kamei H, Nabeshima T, Yamada K
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
    33, 13, 3164
    2008年12月
  • Ovariectomy increases neuronal amyloid-beta binding alcohol dehydrogenase level in the mouse hippocampus.
    Fukuzaki E, Takuma K, Funatsu Y, Himeno Y, Kitahara Y, Gu B, Mizoguchi H, Ibi D, Koike K, Inoue M, Yan SD, Yamada K
    Neurochemistry international
    52, 7, 1358
    2008年06月
  • Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice.
    Ibi D, Takuma K, Koike H, Mizoguchi H, Tsuritani K, Kuwahara Y, Kamei H, Nagai T, Yoneda Y, Nabeshima T, Yamada K
    Journal of neurochemistry
    105, 3, 921
    2008年05月
  • Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits.
    Fukuzaki E, Takuma K, Himeno Y, Yoshida S, Funatsu Y, Kitahara Y, Mizoguchi H, Ibi D, Koike K, Inoue M, Yamada K
    Neuroscience letters
    433, 2, 141
    2008年03月
  • Repeated methamphetamine treatment impairs spatial working memory in rats: reversal by clozapine but not haloperidol.
    Nagai T, Takuma K, Dohniwa M, Ibi D, Mizoguchi H, Kamei H, Nabeshima T, Yamada K
    Psychopharmacology
    194, 1, 21
    2007年09月
  • Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex.
    Nagai T, Takuma K, Kamei H, Ito Y, Nakamichi N, Ibi D, Nakanishi Y, Murai M, Mizoguchi H, Nabeshima T, Yamada K
    Learning & memory (Cold Spring Harbor, N.Y.)
    14, 3, 117
    2007年03月
  • An analog of a dipeptide-like structure of FK506 increases glial cell line-derived neurotrophic factor expression through cAMP response element-binding protein activated by heat shock protein 90/Akt signaling pathway.
    Cen X, Nitta A, Ohya S, Zhao Y, Ozawa N, Mouri A, Ibi D, Wang L, Suzuki M, Saito K, Ito Y, Kawagoe T, Noda Y, Ito Y, Furukawa S, Nabeshima T
    The Journal of neuroscience : the official journal of the Society for Neuroscience
    26, 12, 3335
    2006年03月

講演・口頭発表等

  • 抗精神病薬慢性使用に伴う神経精神毒性におけるHDAC2の役割
    共著
    衣斐 大祐、平松 正行、Gonzalez-Maeso J
    第18回 応⽤薬理シンポジウム
    2016年08月06日
  • 周産期異常免疫応答による神経発達障害における アストロサイトの関与
    共著
    衣斐 大祐、平松 正行、山田 清文
    第46回 日本神経精神薬理学会年会
    2016年07月03日
  • Aβ25-35誘発学習・記憶障害に対する脳内GAT2を介したベタインの効果とアストロサイトの関与
    共著
    衣斐大祐、野村知弘、長尾真希子、間宮隆吉、平松正行
    第127回日本薬理学会近畿部会
    2015年11月20日
  • 既存薬物の再評価から見えてきたトランスレーショナル研究 ~統合失調症を例に~
    衣斐大祐
    第1回環研カンファレンス(名古屋大学環境医学研究所)
    2017年12月22日
  • Role of HDAC2 in psychiatric disorders
    Daisuke Ibi
    Virginia Commonwealth University医学部生理学セミナー
    2017年11月16日
    Virginia Commonwealth University School of Medicine, Department of Physiology

外部資金

  • 2015
    文部科学省
    科学研究費助成事業(学術研究助成基金助成金)
    .抗精神病薬が認知機能に与える影響とHDAC2の役割
    衣斐 大祐
  • 2017
    上原記念生命科学財団 
    5-HT₂ᴀ受容体刺激薬の精神疾患治療薬としての有用性
    衣斐大祐
  • 2018
    市原国際奨学財団
    研究助成金
    幻覚薬のセロトニン5-HT2A受容体刺激薬が示す抗うつ作用の分子機構解明
    2018年
    衣斐大祐


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