Researchers Database

Shuji MIZUMOTO
Faculty of Pharmacy, Department of Pharmacy
Associate Professor
Last Updated :2020/09/19

Basic Information

Basic Information

Career

  • 01 Apr. 2006, 31 Sep. 2013
  • 01 Apr. 2006, 31 Mar. 2008
  • 01 Apr. 2007, 31 Mar. 2011
  • 01 Apr. 2008, 31 Mar. 2010
  • 01 Apr. 2010, 31 Sep. 2013
  • 01 Apr. 2012, 30 Sep. 2013
  • 01 Apr. 2017, 12 Mar. 2018, University of Otago, Dunedin School of Medicine, , Clinical Genetics (Stephen Robertson’s Lab), , Visiting Researcher
  • 01 Oct. 2013, 31 Mar. 2019, Meijo University, Faculty of Pharmacy, Assistant Professor
  • 01 Apr. 2019, Meijo University, Graduate School/Faculty of Pharmacy, Associate Professor

Awards

  • 30 Jun. 2018
  • 01 Sep. 2016
    Glycobiological approaches for bone and skin disorders caused by deficiency of glycosaminoglycans and its role for tumor metastasis
  • 23 Aug. 2015
    9th International Conference on Proteoglycans and 10th Pan-Pacific Connective Tissue Societies Symposium
    Travel Award for 9th International Conference on Proteoglycans and 10th Pan-Pacific Connective Tissue Societies Symposium
    Loss-of-function mutation of glucuronyltransferase-I causes skeletal dysplasia in a consanguineous clan from the island of Nias/Indonesia

Research

Research Area

  • Biological pharmacy
  • Molecular biology
  • Developmental biology
  • Cell biology
  • Human genetics
  • Pathological medical chemistry
  • Applied genomics

Research Keyword

  • Glycobiology
  • Genetic diseases
  • Bone & skin diseases
  • tumor metastasis
  • RAGE
  • proteoglycan
  • chondroitin sulfate
  • heparan sulfate
  • dermatan sulfate

Books

  • 28 Feb. 2020
    ISBN978-4-8158-0981-2
    Joint Work
  • Heparan Sulfate
    Shuji Mizumoto, Kazuyuki Sugahara
    NTS
    12 Aug. 2015
    978-4-86043-409-0
    Joint Work
    pp. 41-51
  • Shuhei Yamada, Shuji Mizumoto, Kazuyuki SUgahara
    NTS
    12 Aug. 2015
    978-4-86043-409-0
    Joint Work
    pp. 62-68
  • Chondroitin Sulfate (In Encyclopedia of Polymeric Nanomaterials)
    Kazuyuki Sugahara, Shuji Mizumoto, Shuhei Yamada
    Springer
    2015
    978-3-642-36199-9 (DOI 10.1007/978-3-642-36199-9_350-1)
    Joint Work
    pp. 389-397
  • Carbohydrate (N-acetylgalactosamine 4-O) sulfotransferase 14 (CHST14): In Handbook of Glycosyltransferases and Related Genes, (Naoyuki Taniguchi, Koichi Honke, Minoru Fukuda, Hisashi Narimatsu, Yoshiki Yamaguchi and Takashi Angata, eds.)
    Tomoki Kosho, Shuji Mizumoto, and Kazuyuki Sugahara
    05 Mar. 2014
    978-4-431-54239-1
    Joint Work
    2nd edition, vol. 2, pp. 1135-1148
  • Bone and Skin Disorders Caused by a Disturbance in the Bioynthesis of Chondroitin Sulfate and Dermatan Sulfate (In Extracellular matrix: Pathobiology and signaling, N. Karamanos ed.)
    Shuji MIZUMOTO and Kazuyuki SUGAHARA
    Walter De Gruyter, Berlin, Germany
    Sep. 2012
    978-3-11-025877-6
    Joint Work
    pp. 97-118
  • Glycosaminoglycan chain analysis and characterization (Glycosylation/Epimerization) : In Methods in Molecular Biology, “Proteoglycans: Methods and Protocols” (Rédini, Françoise, ed.)
    Shuji Mizumoto and Kazuyuki Sugahara
    Humana Press, Springer, New York
    Feb. 2012
    978-1-61779-498-8 (doi: 10.1007/978-1-61779-498-8_7)
    Joint Work
    vol.836, 99-115
  • Aug. 2009
    978-4-944157-84-6
    Joint Work
    pp. 223-230
  • Heparan sulfate synthases and related genes (In Experimental Glycoscience “Glycobiology” (Taniguchi N., Suzuki A., Ito Y., Narimatsu H., Kawasaki T., Hase S., eds)
    Shuji Mizumoto, Hiroshi Kitagawa
    Springer, Tokyo, Japan
    Aug. 2008
    ISBN 978-4-431-77921-6
    Joint Work
    pp. 59-63
  • Heparan sulfate synthase-related genes
    Shuji Mizumoto, Hiroshi Kitagawa, and Kazuyuki Sugahara
    Dec. 2005
    4-7653-1208-9
    Joint Work
    pp. 169-171
  • Biosynthesis of Heparin and Heparan sulfate (In Chemistry and Biology of Heparin and Heparan sulfate, Hari G. Garg, Robert J. Linhardt and Charles A. Hales, eds.)
    Shuji Mizumoto, Hiroshi Kitagawa, and Kazuyuki Sugahara
    Elsevier, Oxford, UK.
    Dec. 2005
    978-0-08-044859-6
    Joint Work
    pp. 203-243
  • Biosynthetic pathways for differential expression of functional chondroitin sulfate and heparin sulfate (In Handbook of Carbohydrate Engineering (Kevin J. Yarema, ed.)
    Shuji Mizumoto*, Toru Uyama*, Tadahisa Mikami, Hiroshi Kitagawa, and Kazuyuki Sugahara
    CRC Press (Taylor & Francis Group), Boca Raton, FL
    May 2005
    9781574444728
    Joint Work
    pp. 289-324

Articles

  • Dermatan sulfate promotes neuronal differentiation in mouse and human stem cells
    Chika Ogura, Kazumi Hirano, Shuji Mizumoto, Shuhei Yamada, and Shoko Nishihara
    Journal of Biochemistry
    Oxford Academic
    in press
    Jul. 2020
  • Systematic investigation of the skin in Chst14−/− mice: a model for skin fragility in musculocontractural Ehlers–Danlos syndrome caused by CHST14 variants (mcEDS-CHST14)
    *Takuya Hirose, *Shuji Mizumoto, Ayana Hashimoto, Yuki Takahashi, Takahiro Yoshizawa, Yuko Nitahara-Kasahara, Naoki Takahashi, Jun Nakayama, Kazushige Takehana, Takashi Okada, Yoshihiro Nomura, Shuhei Yamada, Tomoki Kosho, Takafumi Watanabe (*equal contribution)
    Glycobiology
    Oxford Academic
    in press
    Jul. 2020
  • Pseudodiastrophic dysplasia expands the known phenotypic spectrum of defects in proteoglycan biosynthesis
    Alicia B. Byrne*, Shuji Mizumoto*, Peer Arts, Patrick Yap, Jinghua Feng, Andreas W. Schreiber, Milena Babic, Sarah L. King-Smith, Christopher P. Barnett, Lynette Moore, Kazuyuki Sugahara, Hatice Mutlu-Albayrak, Gen Nishimura, Jan E. Liebelt, Shuhei Yamada, Ravi Savarirayan, Hamish S. Scott (*eaqual cintribution)
    Journal of Medical Genetics
    57, 7
    454-460
    Jul. 2020
  • Delineation of musculocontractural Ehlers-Danlos Syndrome caused by dermatan sulfate epimerase deficiency
    Charlotte Kvist Lautrup*, Keng Wee Teik*, Ai Unzaki*, Shuji Mizumoto, Delphien Syx, Heng Hock Sin, Irene Kibaek Nielsen, Sara Markholt, Shuhei Yamada, Fransiska Malfait, Naomichi Matsumoto, Noriko Miyake, and Tomoki Kosho (* Equally contributing authors)
    Molecular Genetics & Genomic Medicine
    Wiley
    8, 5
    e1197
    May 2020
  • CSGALNACT1-congenital disorder of glycosylation: a mild skeletal dysplasia with advanced bone age
    Shuji Mizumoto*, Andreas R. Janecke*, Azita Sadeghpour, Gundula Povysil, Marie T. McDonald, Sheila Unger, Susanne Greber-Platzer, Kristen L. Deak, Task Force for Neonatal Genomics, Nicholas Katsanis, Andrea Superti-Furga, Erica E. Davis, Shuhei Yamada, Julia Vodopiutz (eaqual cintribution)
    Human Mutation
    Wiley
    41, 3
    655-667
    Mar. 2020
  • Hyaluronidase-4 is produced by mast cells and can cleave serglycin chondroitin sulfate chains into lower molecular weight forms
    Journal of Biological Chemistry
    294, 30
    11458-11472
    26 Jul. 2019
  • Compositional analysis of the glycosaminoglycan family in velvet antlers of Sika deer (Cervus nippon) at different growing stages
    Naoko Takeda-Okuda, Shuji Mizumoto, Zui Zhang, Soo-Ki Kim, Chi-Ho Lee, Byong-Tae Jeon, Yoshinao Z. Hosaka, Kenji Kadomatsu, Shuhei Yamada, and Jun-ichi Tamura
    Glycoconjugate Journal
    Springer
    36, 2
    127-129
    Apr. 2019
  • Structural alteration of glycosaminoglycan side chains and spatial disorganization of collagen networks in the skin of patients with mcEDS-CHST14
    Takuya Hirose, Naoki Takahashi, Prasarn Tangkawattana, Jun Minaguchi, Shuji Mizumoto, Shuhei Yamada, Noriko Miyake, Shujiro Hayashi, Atsushi Hatamochi, Jun Nakayama, Tomomi Yamaguchi, Ayana Hashimoto, Yoshihiro Nomura, Kazushige Takehana, Tomoki Kosho, and Takafumi Watanabe
    Biochimica et Biophysica Acta (BBA) - General Subjects
    Elsevier
    1863, 3
    623-631
    Mar. 2019
  • Identification of Novel LFNG Mutations in Spondylocostal Dysostosis
    Nao Otomo, Shuji Mizumoto, Hsing-Fang Lu, Kazuki Takeda, Belinda Campos-Xavier, Lauréane Mittaz-Crettol, Long Guo, Kazuharu Takikawa, Masaya Nakamura, Shuhei Yamada, Morio Matsumoto, Kota Watanabe, Shiro Ikegawa
    Journal of Human Genetics
    Nature Publishing Group
    64, 3
    261-264
    Mar. 2019
  • Screening of known disease genes in congenital scoliosis
    Kazuki Takeda, Ikuyo Kou, Shuji Mizumoto, Shuhei Yamada, Noriaki Kawakami, Masahiro Nakajima, Nao Otomo, Yoji Ogura, Noriko Miyake, Naomichi Matsumoto, Toshiaki Kotani, Hideki Sudo, Ikuho Yonezawa, Koki Uno, Hiroshi Taneichi, Kei Watanabe, Hideki Shigematsu, Ryo Sugawara, Yuki Taniguchi, Shohei Minami, Masaya Nakamura, Morio Matsumoto, Japan Early Onset Scoliosis Research Group, Kota Watanabe, and Shiro Ikegawa
    Molecular Genetics & Genomic Medicine
    Wiley
    6, 6
    966-974
    Oct. 2018
  • Chondroitin sulfate protects vascular endothelial cells from toxicities of extracellular histones
    Fumihiko Nagano, Tomohiro Mizuno, Shuji Mizumoto, Kengo Yoshioka, Kazuo Takahashi, Naotake Tsuboi, Shoichi Maruyama, Shuhei Yamada, and Tadashi Nagamatsu
    European Journal of Pharmacology
    826, -
    48-55
    05 May 2018
  • Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica
    Chan, W.L., M. Steiner, J. Egerer, B. Busse, S. Mizumoto, J. Pestka, H. Zhang, I. Hausser, L.A. Khayal, C.E. Ott, M. Kolanczyk, B. Willie, T. Schinke, C. Paganini, A. Rossi, K. Sugahara, M. Amling, P. Knaus, D. Chan, S. Mundlos, and U. Kornak
    PLoS Genetics
    14, 3
    e1007242
    21 Mar. 2018
  • Vascular abnormalities in the placenta of Chst14-/- fetuses: implications in the pathophysiology of perinatal lethality of the murine model and vascular lesions in human CHST14/D4ST1 deficiency
    Takahiro Yoshizawa, Shuji Mizumoto, Yuki Takahashi, Shin Shimada, Kazuyuki Sugahara, Jun Nakayama, Shin'ichi Takeda, Yoshihiro Nomura, Yuko Nitahara-Kasahara, Takashi Okada, Kiyoshi Matsumoto, Shuhei Yamada, Tomoki Kosho
    Glycobiology
    Oxford University Press
    28, 2
    80-89
    01 Feb. 2018
  • The reduction of heparan sulphate in the glomerular basement membrane does not augment urinary albumin excretion
    Satoshi Aoki, Akiko Saito-Hakoda, Takeo Yoshikawa, Kyoko Shimizu, Kiyomi Kisu, Susumu Suzuki, Kiyoshi Takagi, Shuji Mizumoto, Shuhei Yamada, Toin H. van Kuppevelt, Atsushi Yokoyama, Taiji Matsusaka, Hiroshi Sato, Sadayoshi Ito, Akira Sugawara
    Nephrology Dialysis Transplantation
    Oxford University Press
    33, 1
    26-33
    01 Jan. 2018
  • Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus
    Yusuke Mii, Takayoshi Yamamoto, Ritsuko Takada, Shuji Mizumoto, Makoto Matsuyama, Shuhei Yamada, Shinji Takada, Masanori Taira
    Nature Communications
    Nature Publishing Group
    8, 1
    1973
    07 Dec. 2017
  • Defect in dermatan sulfate in urine of patients with Ehlers-Danlos syndrome caused by a CHST14/D4ST1 deficiency
    *Shuji Mizumoto, Tomoki Kosho, Atsushi Hatamochi, Tomoko Honda, Tomomi Yamaguchi, Nobuhiko Okamoto, Noriko Miyake, Shuhei Yamada, and *Kazuyuki Sugahara (*corresponding author)
    Clinical Biochemistry
    Elsevier
    50, 12
    670-677
    Aug. 2017
  • Identification of biallelic EXTL3 mutations in a novel type of spondylo-epi-metaphyseal dysplasia
    *Long Guo, *Nursel H Elcioglu, *Shuji Mizumoto, Zheng Wang, Bilge Noyan, Hatice M Albayrak, Shuhei Yamada, Naomichi Matsumoto, Noriko Miyake, Gen Nishimura, Shiro Ikegawa (equal contribution)
    Journal of Human Genetics
    Nature Publishing Group
    62, 8
    797-801
    Aug. 2017
  • Chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) deficiency results in a mild skeletal dysplasia and joint laxity
    Julia Vodopiutz, Shuji Mizumoto, Ekkehard Lausch, Antonio Rossi, Sheila Unger, Nikolaus Janocha, Rainer Seidl, Susanne Greber-Platzer, Shuhei Yamada, Thomas Müller, Bernd Jilma, Rudolf Ganger, Andrea Superti-Furga, Shiro Ikegawa, Kazuyuki Sugahara, Andreas R. Janecke
    Human Mutation
    38, 1
    34-38
    Jan. 2017
  • Functional validation of novel compound heterozygous variants in B3GAT3 resulting in severe osteopenia and fractures: expanding the disease phenotype
    *Florian Job, *Shuji Mizumoto, Laurie Smith, Natario Couser, Ashley Brazil, Howard Saal4, Melanie Patterson5, Margaret I. Gibson5, Sarah Soden6, Neil Miller7, Isabelle Thiffault5, Carol Saunders5, Shuhei Yamada, Katrin Hoffmann, Kazuyuki Sugahara, Emily Farrow. (*equal contribution)
    BMC Medical Genetics
    17, 1
    86
    21 Nov. 2016
  • Pivotal role of carbohydrate sulfotransferase 15 in fibrosis and mucosal healing in mouse colitis
    Kenji Suzuki, Somasundaram Arumugam, Junji Yokoyama, Yusuke Kawauchi, Yutaka Honda, Hiroki Sato, Yutaka Aoyagi, Shuji Terai, Kazuichi Okazaki, Yasuo Suzuki, Shuji Mizumoto, Kazuyuki Sugahara, Raja Atreya, Markus F. Neurath, Kenichi Watanabe, Taishi Hashiguchi, Hiroyuki Yoneyama, Hitoshi Asakura
    PLoS ONE
    11, 7
    e0158967
    Jul. 2016
  • Skeletal dysplasia in a consanguineous clan from the island of Nias/Indonesia is caused by a novel mutation in B3GAT3(査読付き論文)
    *Birgit S. Budde, *Shuji Mizumoto, Ryo Kogawa, Christian Becker, Janine Altmüller, Holger Thiele, Franz Rüschendorf, Mohammad R. Toliat, Gerrit Kaleschke, Johannes M. Hämmerle, Wolffang Höhne, Kazuyuki Sugahara, Peter Nürnberg, Ingo Kennerknecht. (*equal contribution)
    Human Genetics
    134, 7
    691-704
    Jul. 2015
  • Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor(査読付き論文)
    Marina Koutsioumpa, Evangelia Poimenidi, Evangelia Pantazaka, Christina Theodoropoulou, Angeliki Skoura, Vasileios Megalooikonomou, Nelly Kieffer, Jose Courty, Shuji Mizumoto, Kazuyuki Sugahara, and Evangelia Papadimitriou.
    Molecular Cancer
    14, 1
    19
    03 Feb. 2015
  • Sulfation patterns of exogenous chondroitin sulfate affect chondrogenic differentiation of ATDC5 cells(査読付き論文)
    Daisuke Kawamura, Tadanao Funakoshi, Shuji Mizumoto, Kazuyuki Sugahara, and Norimasa Iwasaki
    Journal of Orthopaedic Science
    Springer
    19, 6
    1028-1035
    11 Sep. 2014
  • Effects of sesamin on the biosynthesis of chondroitin sulfate proteoglycans in human articular chondrocytes in primary culture
    Peraphan Pothacharoen, Sumet Najarus, Jongkolnee Settakorn, Shuji Mizumoto, Kazuyuki Sugahara, and Prachya Kongtawelert
    Glycoconjugate Journal
    31, 3
    221-230
    Apr. 2014
  • Proteoglycans and glycosaminoglycans improve toughness of biocompatible double network hydrogelsions
    Yu Zhao, Tasuku Nakajima, Jing Jing Yang, Takayuki Kurokawa, Jian Liu, Jishun Lu, Shuji Mizumoto, Kazuyuki Sugahara, Nobuto Kitamura, Kazunori Yasuda, A. U. D. Daniels, and Jian Ping Gong
    Advanced Materials
    26, 3
    436-442
    Jan. 2014
  • De novo mutations in SLC35A2 encoding a UDP-galactose transporter cause early-onset epileptic encephalopathy
    Hirofumi Kodera, Kazuyuki Nakamura, Hitoshi Osaka, Yoshihiro Maegaki, Kazuhiro Haginoya, Shuji Mizumoto, Mitsuhiro Kato, Nobuhiko Okamoto, Mizue Iai, Yukiko Kondo, Kiyomi Nishiyama, Yoshinori Tsurusaki, Mitsuko Nakashima, Noriko Miyake, Kazuyuki Sugahara, Isao Yuasa, Yoshinao Wada, Naomichi Matsumoto, and Hirotomo Saitsu
    Human Mutation
    34, 12
    1708-1714
    Dec. 2013
  • Clinical and radiographic features of the autosomal recessive form of brachyolmia caused by PAPSS2 mutations
    Aritoshi Iida*, Pelin Ozlem Simsek-Kiper*, Shuji Mizumoto*, Touma Hoshino, Nursel Elcioglu, Eva Horemuzova, Stefan Geiberger, Gozde Yesil, Hulya Kayserili, Gulen Eda Unite, Koray Boduroglu, Shigehiko Watanabe, Hirofumi Ohashi, Yasemin Alanay, Kazuyuki Sugahara, Gen Nishimura, and Shiro Ikegawa. (*equal contribution)
    Human Mutation
    34, 10
    1381-1386
    Oct. 2013
  • Loss of dermatan sulfate epimerase (DSE) function results in musculocontractural Ehlers-Danlos syndrome
    *Thomas Müller, *Shuji Mizumoto, *Indrajit Suresh, Yoshie Komatsu, Julia Vodopiutz, Munis Dündar, Volker Straub, Arno Lingenhel, Andreas Melmer, Silvia Lechner, Johannes Zschocke, Kazuyuki Sugahara, Andreas R Janecke (*equal contribution)
    Human Molecular Genetics
    22, 18
    3761-3772
    Sep. 2013
  • Interaction of chondroitin sulfate and dermatan sulfate from various biological sources with heparin-binding growth factors and cytokines
    Shuji Mizumoto, Duriya Fongmoon, And Kazuyuki Sugahara
    Glycoconjugate Journal
    30, 6
    619-632
    Aug. 2013
  • Mutations in B3GALT6, which Encodes a Glycosaminoglycan Linker Region Enzyme, Cause a Spectrum of Skeletal and Connective Tissue Disorders
    Masahiro Nakajima*, Shuji Mizumoto*, Noriko Miyake*, Ryo Kogawa, Aritoshi Iida, Hironori Ito, Hiroshi Kitoh, Aya Hirayama, Hiroshi Mitsubuchi, Osamu Miyazaki, Rika Kosaki, Reiko Horikawa, Angeline Lai, Roberto Mendoza-Londono, Lucie Dupuis, David Chitayat, Andrew Howard, Gabriela F. Leal, Denise Cavalcanti, Yoshinori Tsurusaki, Hirotomo Saitsu, Shigehiko Watanabe, Ekkehart Lausch, Sheila Unger, Luisa Bonafé, Hirofumi Ohashi, Andrea Superti-Furga, Naomichi Matsumoto, Kazuyuki Sugahara, Gen Nishimura and Shiro Ikegawa. (*equal contribution)
    American Journal of Human Genetics
    92, 6
    927-934
    Jun. 2013
  • Highly sulfated hexasaccharide sequences isolated from chondroitin sulfate of shark fin cartilage: insights into the sugar sequences with bioactivities.
    *Shuji Mizumoto, *Saori Murakoshi, *Kittiwan Kalayanamitra, Sarama Sathyaseelan Deepa, Shigeyuki Fukui, Prachya Kongtawelert, Shuhei Yamada, and Kazuyuki Sugahara (*equal contribution)
    Glycobiology
    23, 2
    155-168
    Feb. 2013
  • Expression of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase involved in chondroitin sulfate synthesis is responsible for pulmonary metastasis
    *Shuji Mizumoto, *Moto Watanabe, Shuhei Yamada, and Kazuyuki Sugahara (*equal contribution)
    BioMed Research International
    2013
    656319
    Feb. 2013
  • Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4)
    Tomoyuki Kaneiwa, Anzu Miyazaki, Ryo Kogawa, Shuji Mizumoto, Kazuyuki Sugahara, and Shuhei Yamada
    Journal of Biological Chemistry
    287, 50
    42119-42128
    Dec. 2012
  • Hyaluronidases have strong hydrolytic activity toward chondroitin 4-sulfate comparable with that toward hyaluronan
    Tomoko Honda, Tomoyuki Kaneiwa, Shuji Mizumoto, Kazuyuki Sugahara, Shuhei Yamada
    Biomolecules
    2, 4
    549-563
    Nov. 2012
  • Receptor for Advanced Glycation End Products (RAGE) Functions as a Receptor for Specific Sulfated Glycosaminoglycans, and Anti-RAGE Antibody or The Sulfated Glycosaminoglycans Delivered in vivo Inhibit Pulmonary Metastasis of Tumor Cells
    Shuji Mizumoto*, Jun Takahashi*, And Kazuyuki Sugahara
    Journal of Biological Chemistry
    287, 23
    18985-18994
    Jun. 2012
  • Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype
    Anurag Purushothaman, Douglas R. Hurst, Claudio Pisano, Shuji Mizumoto, Kazuyuki Sugahara, and Ralph D. Sanderson
    Journal of Biological Chemistry
    286, 35
    30377-30383
    Sep. 2011
  • Involvement of HNK-1 Sulfotransferase in the Biosynthesis of Chondroitin Sulfate and the GlcUA(3-O-sulfate)-Gal-Gal-Xyl Tetrasaccharide Found in -Thrombomodulin from Human Urine
    Taishi Hashiguchi, Shuji Mizumoto, Yuko Nishimura, Jun-ichi Tamura, Shuhei Yamada, and Kazuyuki Sugahara
    Journal of Biological Chemistry
    286, 38
    33003-33011
    Sep. 2011
  • Faulty initiation of proteoglycan synthesis causes cardiac and joint defects
    *Sevjidmaa Baasanjav, *Lihadh Al-Gazali, *Taishi Hashiguchi, Shuji Mizumoto, Bjoern Fischer, Denise Horn, Dominik Seelow, Bassam R. Ali, Samir A.A. Aziz, Ruth Langer, Ahmed A.H. Saleh, Christian Becker, Gudrun Nürnberg, Vincent Cantagrel, Joseph G. Gleeson, Delphine Gomez, Jean-Baptiste Michel, Sigmar Stricker, Tom H. Lindner, Peter Nürnberg, Kazuyuki Sugahara, Stefan Mundlos, Katrin Hoffmann
    American Journal of Human Genetics
    89, 1
    15-27
    Jul. 2011
  • Dermatan sulfate epimerase 2 is the predominant isozyme in the formation of the chondroitin sulfate/dermatan sulfate hybrid structure in postnatal developing mouse brain
    Chizuru Akatsu, Shuji Mizumoto, Tomoyuki Kaneiwa, Marco Maccarana, Anders Malmström, Shuhei Yamada, and Kazuyuki Sugahara
    Glycobiology
    21, 5
    565-574
    May 2011
  • Demonstration of the hepatocyte growth factor signaling pathway in the in vitro neuritogenic activity of chondroitin sulfate from ray fish cartilage
    Taishi Hashiguchi, Takanari Kobayashi, Duriya Fongmoon, Ajaya Kumar Shetty, Shuji Mizumoto, Nobuyuki Miyamoto, Toshikazu Nakamura, Shuhei Yamada, and Kazuyuki Sugahara
    Biochimica et Biophysica Acta (General Subjects)
    1810, 4
    406-413
    Apr. 2011
  • Synthesis of the glycosaminoglycan-protein linkage tetrasaccharide peptide moieties of betaglycan, which serve as amino sugar acceptor for enzymatic glycosyl transfer
    Jun-ichi Tamura, Tomomi Nakamura-Yamamoto, Yuko Nishimura, Shuji Mizumoto, Jun Takahashi, Kazuyuki Sugahara
    Carbohydrate Research
    345, 15
    2115-2123
    Oct. 2010
  • Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome
    *Noriko Miyake, *Tomoki Kosho, *Shuji Mizumoto, Tatsuya Furuichi, Atsushi Hatamochi, Yoji Nagashima, Eiichi Arai, Kazuo Takahashi, Rie Kawamura, Keiko Wakui, Jun Takahashi, Hiroyuki Kato, Hiroshi Yasui, Tadao Ishida, Hirofumi Ohashi, Gen Nishimura, Masaaki Shiina, Hirotomo Saitsu, Yoshinori Tsurusaki, Hiroshi Doi, Yoshimitsu Fukushima, Shiro Ikegawa, Shuhei Yamada, Kazuyuki Sugahara, Naomichi Matsumoto
    Human Mutation
    31, 8
    966-974
    Aug. 2010
  • Development of a mouse monoclonal antibody against the chondroitin sulfate-protein linkage region derived from shark cartilage
    Chizuru Akatsu, Duriya Fongmoon, Shuji Mizumoto, Jean-Claude Jacquinet, Prachya Kongtawelert, Shuhei Yamada, and Kazuyuki Sugahara
    Glycoconjugate Journal
    27, 4
    387-399
    May 2010
  • Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence
    Tomoyuki Kaneiwa, Shuji Mizumoto, Kazuyuki Sugahara, and Shuhei Yamada
    Glycobiology
    20, 3
    300-309
    Mar. 2010
  • Analysis of the structure and neuritogenic activity of chondroitin sulfate/dermatan sulfate hybrid chains from porcine fetal membranes
    Taishi Hashiguchi, Shuji Mizumoto, Shuhei Yamada, and Kazuyuki Sugahara
    Glycoconjugate Journal
    27, 1
    49-60
    Jan. 2010
  • Isolation and characterization of a novel chondroitin sulfate from squid liver integument rich in N-acetylgalactosamine(4,6-O-disulfate) and glucuronate(3-O-sulfate) residues
    Ajaya K Shetty*, Takanari Kobayashi*, Shuji Mizumoto, Masaki Narumi, Yoshiaki Kudo, Shuhei Yamada, Kazuyuki Sugahara
    Carbohydrate Research
    344, 12
    1526-1532
    Aug. 2009
  • Important role of heparan sulfate in postnatal islet growth and insulin secretion
    Iwao Takahashi, Naoya Noguchi, Koji Nata, Shuhei Yamada, Tomoyuki Kaneiwa, Shuji Mizumoto, Takayuki Ikeda, Kazushi Sugihara, Masahide Asano, Takeo Yoshikawa, Akiyo Yamauchi, Nausheen Jamal Shervani, Akira Uruno, Ichiro Kato, Michiaki Unno, Kazuyuki Sugahara, Shin Takasawa, Hiroshi Okamoto, Akira Sugawara
    Biochemical and Biophysical Research Communications
    383, 1
    113-118
    May 2009
  • Omani type spondyloepiphyseal dysplasia with cardiac involvement caused by a missense mutation in CHST3
    Beyhan Tuysuz, Shuji Mizumoto, Kazuyuki Sugahara, Ahmet Çelebi, Stefan Mundlos, Seval Turkmen
    Clinical Genetics
    75, 4
    375-383
    Apr. 2009
  • Chondroitin 4-O-sulfotransferase-1 is required for somitic muscle development and motor axon guidance in zebrafish
    Shuji Mizumoto*, Tadahisa Mikami*, Daiki Yasunaga, Naoki Kobayashi, Hajime Yamauchi, Ayumi Miyake, Nobuyuki Itoh, Hiroshi Kitagawa, and Kazuyuki Sugahara
    Biochemical Journal
    419, 2
    387-399
    Apr. 2009
  • Involvement of highly sulfated chondroitin sulfate in the metastasis of the Lewis lung carcinoma cells
    Fuchuan Li, Gerdy B. ten Dam, Sengottuvelan Murugan, Shuhei Yamada, Taishi Hashiguchi, Shuji Mizumoto, Kayoko Oguri, Minoru Okayama, Toin H. van Kuppevelt, and Kazuyuki Sugahara
    Journal of Biological Chemistry
    283, 49
    34294-34304
    Dec. 2008
  • Spondyloepiphyseal dysplasia, Omani type: further definition of the phenotype
    Mirjam H.H. van Roij*, Shuji Mizumoto*, Shuhei Yamada, Tim Morgan, M.B. Tan-Sindhunata, H. Meijers-Heijboer, J.I.L.M. Verbeke, David Markie, Kazuyuki Sugahara, Stephen P. Robertson
    American Journal of Medical Genetics
    164, 18
    2376-2384
    Sep. 2008
  • Identification of a novel chondroitin hydrolase in Caenorhabditis elegans
    Tomoyuki Kaneiwa*, Shuhei Yamada*, Shuji Mizumoto, Adriana M Montaño, Shohei Mitani, and Kazuyuki Sugahara
    Journal of Biological Chemistry
    283, 22
    14971-14979
    May 2008
  • Functions of chondroitin sulfate/dermatan sulfate chains in brain development: Critical roles of E and iE disaccharide units recognized by a single chain antibody GD3G7
    Anurag Purushothaman, Junko Fukuda, Shuji Mizumoto, Gerdy B. ten Dam, Toin H. van Kuppevelt, Hiroshi Kitagawa, Tadahisa Mikami, and Kazuyuki Sugahara
    Journal of Biological Chemistry
    282, 27
    19442-19452
    Jun. 2007
  • Occurrence of a non-sulfated chondroitin proteoglycan in the dried saliva of collocalia swiftlets (edible bird's nest)
    Hiroki Nakagawa, Yoichiro Hama, Toshihisa Sumi, Su-Chen Li, Karol Maskos, Kittiwan Kalayanamitra, Shuji Mizumoto, Kazuyuki Sugahara, and Yu-The Li
    Glycobiology
    17, 2
    157-164
    Feb. 2007
  • Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum: Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases
    Chie Mitsunaga*, Tadahisa Mikami*, Shuji Mizumoto, Junko Fukuda, and Kazuyuki Sugahara
    Journal of Biological Chemistry
    281, 28
    18942-18952
    Jul. 2006
  • Specificities of three distinct chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as acceptor: Implication of differential roles in dermatan biosynthesis
    Tadahisa Mikami*, Shuji Mizumoto*, Naohide Kago, Hiroshi Kitagawa, and Kazuyuki Sugahara
    Journal of Biological Chemistry
    278, 38
    36115-36127
    Sep. 2003

Presentations

  • Congenital bone and skin disorders caused by defect in glycosaminoglycans
    Shuji Mizumoto
  • Pseudodiastrophic dysplasia caused by mutations in glucronyltransferase-I and calcium-activated nucleotidase-1
    Shuji Mizumoto, Alicia B Byrne, Peer Arts, Patrick Yap, Jinghua Feng, Andreas W Schreiber, Milena Babic, Sarah L King-Smith, Christopher P Barnett, Lynette Moore, Kazuyuki Sugahara, Hatice Mutlu-Albayrak, Gen Nishimura, Jan E Liebelt, Shuhei Yamada, Ravi Savarirayan, Hamish S Scott
  • Pathogenic variants in glucuronyltransferase-I and calcium-activated nucleotidase-1 cause pseudodiastrophic dysplasia
    Shuji Mizumoto, Alicia B Byrne, Peer Arts, Patrick Yap, Jinghua Feng, Andreas W Schreiber, Milena Babic, Sarah L King-Smith, Christopher P Barnett, Lynette Moore, Kazuyuki Sugahara, Hatice Mutlu-Albayrak, Gen Nishimura, Jan E Liebelt, Shuhei Yamada, Ravi Savarirayan, Hamish S Scott
    12th International Symposium on Glycosyltransferases (GlycoT2020)
  • Loss-of-function mutations in CSGALNACT1 cause a skeletal dysplasia
    Shuji Mizumoto, Andreas R. Janecke, Azita Sadeghpour, Gundula Povysil, Marie T. McDonald, Sheila Unger, Susanne Greber-Platzer, Nicholas Katsanis, Andrea Superti-Furga, kazuyuki Sugahara, Erica E. Davis, Shuhei Yamada, Julia Vodopiutz
  • Shuji Mizumoto
  • Proteoglycan defect-related EDS
    Shuji Mizumoto
    Scientific Meeting on The Rare Types of Ehlers-Danlos Syndromes
    The Ehlers-Danlos Society
  • A skeletal dysplasia with joint laxity and advanced bone age is caused by loss-of-function mutations in CSGALNACT1
    Shuji Mizumoto, Andreas R. Janecke, Azita Sadeghpour, Erica E. Davis, Kazuyuki Sugahara, Shuhei Yamada, Julia Vodopiutz
    11th international Conference on Proteoglyans
  • Defects in biosynthesis of glycosaminoglycan side chains of proteoglycans cause hereditary bone, skin, heart, and immune disorders
    Shuji Mizumoto
    Proteoglycans Future Leaders Symposium 2019
  • Congenital bone, joint, skin, heart, immune, and neurological disorders caused by defect in side chains of proteoglycans
    Shuji Mizumoto
  • A skeletal dysplasia was caused by mutations in CSGALNACT1 encoding glycosyltransferase responsible for chondroitin sulfate biosynthesis
    Shuji Mizumoto, Andreas R. Janecke, Azita Sadeghpour, Gundula Povysil, Marie T. McDonald, Sheila Unger, Susanne Greber-Platzer, Nicholas Katsanis, Andrea Superti-Furga, Kazuyuki Sugahara, Erica E. Davis, Shuhei Yamada, Julia Vodopiutz
    Japanese Carbohydrate Research Society
  • Biallelic loss-of-function mutations in CSGALNACT1 cause a skeletal dysplasia with advanced bone age
    Shuji Mizumoto, Andreas R. Janecke, Azita Sadeghpour, Gundula Povysil, Marie T. McDonald, Sheila Unger, Susanne Greber-Platzer, Task Force for Neonatal Genomics, Nicholas Katsanis, Andrea Superti-Furga, Kazuyuki Sugahara, Erica E. Davis, Shuhei Yamada, Julia Vodopiutz
    43rd Human Genetics Society of Australasia Annual Scientific Meeting (HGSA2019)
    The Human Genetics Society of Australasia
  • ◯Shuji Mizumoto
  • Musculocontractural Ehlers-Danlos syndrome caused by a CHST14 deficiency results in defect in urinary dermatan sulfate
    Shuji Mizumoto, Tomoki Kosho, Atsushi Hatamochi, Tomoko Honda, Tomomi Yamaguchi, Nobuhiko Okamoto, Noriko Miyake, Kazuyuki Sugahara, Shuhei Yamada
    The International Symposium on the Ehlers-Danlos Syndromes
    The Ehlers-Danlos Society
  • A mouse model for gerodermia osteodysplastica, Gorab-null mice, shows a reduction in glycosaminoglycans
    Wing Lee Chan, Magdalena Steiner Tomasz Witkos, Johannes Egerer, Björn Busse, Shuji Mizumoto, Jan M. Pestka, Haikuo Zhang, Ingrid Hausser, Layal Abo Khayal, Claus-Eric Ott, Mateusz Kolanczyk, Bettina Willie, Thorsten Schinke, Chiara Paganini, Antonio Rossi, Kazuyuki Sugahara, Michael Amling, Petra Knaus, Danny Chan, Martin Lowe, Stefan Mundlos, Uwe Kornak
    The 91st Annual Meeting of Japanese Biochemical Society
    Japanese Biochemical Society
  • Spondyloepimetaphyseal dysplasia with immune deficiency caused by mutation in EXTL3
    Shuji Mizumoto, Long Guo, Nursel H Elcioglu, Zheng Wang, Bilge Noyan, Hatice M Albayrak, Naomichi Matsumoto, Noriko Miyake, Gen Nishimura, Shuhei Yamada, Shiro Ikegawa
    The 37th Annual Meeting of Japanese Society of Carbohydrate Research
    The Japanese Society of Carbohydrate Research
  • ◯Shuji Mizumoto
  • Defects in Biosynthesis of Glycosaminoglycans Cause Hereditary Bone, Skin, Heart, Immune, and Neurological Disorders
    ◯Shuji Mizumoto
    National Glycoengineering Research Center (NGRC) Seminar, Quindao Campus of Shandong University, China
    National Glycoengineering Research Center (NGRC) Seminar, Quindao Campus of Shandong University, China
  • A novel type of spondylo-epi-metaphyseal dysplasia with immuno-deficiency caused by mutation in EXTL3 encoding a glycosyltransferase responsible for biosynthesis of heparan sulfate
    ◯Shuji Mizumoto, Long Guo, Nursel H Elcioglu, Zheng Wang, Bilge Noyan, Hatice M Albayrak, Naomichi Matsumoto, Noriko Miyake, Gen Nishimura, Shuhei Yamada, and Shiro Ikegawa
    The 11th International Symposium on Glycosyltransferases (GlycoT 2018)
  • Long Guo, Nursel H Elcioglu, ◯Shuji Mizumoto, Zheng Wang, Bilge Noyan, Hatice M Albayrak, Shuhei Yamada, Naomichi Matsumoto, Noriko Miyake, Gen Nishimura1, Shiro Ikegawa
  • Integrated neuroglycobiology for proteoglycans and chondroitin sulfate-binding proteins
    ◯Shuji Mizumoto, Yusuke Yoshikawa, Shuhei Yamada, Kosei Takeuchi, Yoshiaki Nakayama, Akira Kurosaka, Keiichiro Matsushima, Nobuyuki Miyamoto, Wataru Takada, Hirofumi Kodera, Naomichi Matsumoto, Hirotomo Saitsu, Gunnar Dick, James W. Fawcett, Jessica C. F. Kwok, and Kazuyuki Sugahara
    平成28年度 新学術領域「神経糖鎖生物学」最終シンポジウム
    新学術領域「神経糖鎖生物学」
  • ◯Shuji Mizumoto, Florian Job, Laurie Smith, Natario Couser, Ashley Brazil, Howard Saul, Melanie Patterson, Margaret I. Gibson, Sarah Soden, Neil Miller, Isabelle Thiffault, Carol Saunders, Shuhei Yamada, Katrin Hoffman, Kazuyuki Sugahara, Emily Farrow
  • Multiple fractures and severe osteoporosis caused by mutations in a glycosyltransferase responsible for biosynthesis of glycosaminoglycans
    ◯Shuji Mizumoto, Florian Job, Laurie Smith, Natario Couser, Ashley Brazil, Howard Saul, Melanie Patterson, Margaret I. Gibson, Sarah Soden, Neil Miller, Isabelle Thiffault, Carol Saunders, Shuhei Yamada, Katrin Hoffman, Kazuyuki Sugahara, Emily Farrow
  • 第19回日本糖質学会奨励賞受賞講演「グリコサミノグリカンの生合成異常による骨・皮膚疾患の糖鎖解析と癌転移における役割」
    ◯水本秀二
    日本糖質学会
  • Quantification of dermatan sulfate from urine in Ehlers-Danlos syndrome caused by carbohydrate sulfotransferase 14 (CHST14)/dermatan 4-O-sulfotransferase-1 (D4ST1) deficiency
    ◯Shuji Mizumoto, Tomoki Kosho, Atsushi Hatamochi, Tomoko Honda, Shuhei Yamada, and Kazuyuki Sugahara
    ICS 2016 (XXVIII International Carbohydrate)
  • Multiple fractures and severe osteoporosis caused by mutations in a glycosyltransferase responsible for biosynthesis of glycosaminoglycans
    ◯S Mizumoto, F Job, L Smith, N Couser, A Brazil, H Saul, M Patterson, MI Gibson, S Soden, N Miller, I Thiffault, C Saunders, S Yamada, K Hoffman, K Sugahara, E Farrow
    GlycoT 2016 (The 10th International Symposium on Glycosyltransferases)
  • Detection of the degradation activities of chondroitin sulfate and hyaluronan in mouse brain as well as cultured cell lines
    ◯Shuji Mizumoto, Tomomasa Yamanaka, Sae Nagai, and Shuhei Yamada
    The 3rd International Symposium on Glyco-Neuroscience
  • Skeletal dysplasia in a consanguineous clan from the island of Nias/Indonesia is caused by mutation in glucuronyltransferase-I
    ◯Shuji Mizumoto, Birgit S. Budde, Ryo Kogawa, Christian Becker, Janine Altmuller, Holger Thiele, Franz Rüschendorf, Mohammad R. Toliat, Gerrit Kaleschke5, Johannes M. Hammerle, Wolffang Hohne3, Kazuyuki Sugahara, Peter Nurnberg, Ingo Kennerknecht
    Anural Meeting of Biochemistry and Molecular Biology 2015,
  • Loss-of-function mutation of glucuronyltransferase-I causes skeletal dysplasia in a consanguineous clan from the island of Nias/Indonesia
    ◯Shuji Mizumoto, Birgit S. Budde, Ryo Kogawa, Christian Becker, Janine Altmüller, Holger Thiele, Franz Rüschendorf, Mohammad R. Toliat, Gerrit Kaleschke, Johannes M. Hämmerle, Wolffang Höhne, Kazuyuki Sugahara, Peter Nürnberg, Ingo Kennerknecht.
    9th International Conference on Proteoglycans and 10th Pan-Pacific Connective Tissue Societies Symposium
    Korean Society of Matrix Biology
  • ◯Shuji Mizumoto, Birgit S. Budde, Ryo Kogawa, Christian Becker, Janine Altmüller, Holger Thiele, Franz Rüschendorf, Mohammad R. Toliat, Gerrit Kaleschke, Johannes M. Hämmerle, Wolffang Höhne, Kazuyuki SUgahara, Peter Nürnberg, Ingo Kennerknecht
  • Spondyloepimetaphyseal dysplasia and Ehlers-Danlos syndrome caused by mutations of glycosaminoglycan biosynthetic enzymes, GalT-II and DS-epimerase
    ○Shuji Mizumoto, Masahiro Nakajima, Thomas Müller, Noriko Miyake, Ryo Kogawa, Yoshie Komatsu, Naomichi Matsumoto, Andreas R Janecke, Shiro Ikegawa, Kazuyuki Sugahara
    Joint Meeting of the Society for Glycobiology and the Japanese Society of Carbohydrate Research
  • A numbers of genetic bone and skin disorders caused by defect in side chains of proteoglycans
    ○Shuji MIZUMOTO
  • Mutations in PAPS synthase 2 cause an autosomal recessive form of brachyolmia
    ○Shuji Mizumoto, Aritoshi Iida, Pelin Özlem Simsek-Kiper, Touma Hoshino, Nursel Elcioglu, Eva Horemuzova, Stefan Geiberger, Gozde Yesil, Hülya Kayserili, Gülen Eda Utine, Koray Boduroglu, Shigehiko Watanabe, Hirofumi Ohashi, Yasemin Alanay, Gen Nishimura, Shiro Ikegawa, Kazuyuki Sugahara
  • A numbers of genetic bone and skin disorders caused by defect of glycosaminoglycans (Invited)
    Shuji Mizumoto
  • Autosomal recessive form of brachyolmia caused by a mutation in PAPS synthase 2
    ○Shuji Mizumoto, Aritoshi Iida, Pelin Özlem Simsek-Kiper, Touma Hoshino, Nursel Elcioglu, Eva Horemuzova, Stefan Geiberger, Gozde Yesil, Hülya Kayserili, Gülen Eda Utine, Koray Boduroglu, Shigehiko Watanabe, Hirofumi Ohashi, Yasemin Alanay, Gen Nishimura, Shiro Ikegawa, Kazuyuki Sugahara
    日本薬学会第134回年会
  • Novel highly sulfated hexasaccharide sequences isolated from chondroitin sulfate of shark fin cartilage
  • Receptor for Advanced Glycation End-products (RAGE) functions as a receptor for glycosaminoglycans involved in pulmonary metastasis
    ◯Shuji MIZUMOTO, Jun TAKAHASHI, Kazuyuki SUGAHARA
    The 10th International Symposium for Future Drug Discovery and Medical Care
  • RAGE is a functional receptor for chondroitin sulfate involved in pulmonary metastasis of tumor cells
    ○Shuji Mizumoto, Jun Takahashi, and Kazuyuki Sugahara
  • Novel highly sulfated hexasaccharide sequences isolated from chondroitin sulfate of shark fin cartilage: Insights into the sugar sequences involved in brain development
    ○Shuji Mizumoto, Saori Murakoshi, Kittiwan Kalayanamitra, Sarama Sathyaseelan Deepa, Shigeyuki Fukui, Prachya Kongtawelert, Shuhei Yamada, and Kazuyuki Sugahara
  • Novel Larsen-like syndrome caused by a mutation in glucuronyltransferase-I
  • Loss-of-function mutation of glucuronyltransferase-I causes Larsen-like syndrome
    S. Baasanjav, L. Al-Gazali, T. Hashiguchi, ◯S. Mizumoto, B. Fischer, D. Horn, D. Seelow, B. R. Ali, S.A.A. Aziz, R. Langer, A. A.H. Saleh, C. Becker, G. Nürnberg, V. Cantagrel, J. G. Gleeson, D. Gomez, J.-B. Michel, S. Stricker, T. H. Lindner, P. Nürnberg, K. Sugahara, S. Mundlos, K. Hoffmann
    7th International Conference on Proteoglycans
    Matrix & Biology Society
  • Loss-of-function mutations of dermatan 4-O-sulfotransferase-1 cause a new type of Ehlers-Danlos syndrome
    ◯Shuji Mizumoto, Noriko Miyake, Tomoki Kosho, Shuhei Yamada, Kazuyuki Sugahara, and Naomichi Matsumoto
  • A deficiency of glycosaminoglycans causes cardiac and joint disorders
    Sevjidmaa Baasanjav, Lihadh Al-Gazali, Taishi Hashiguchi, ○Shuji Mizumoto, Bjoern Fischer, Denise Horn, Dominik Seelow, Bassam R. Ali, Samir A.A. Aziz, Ruth Langer, Ahmed A.H. Saleh, Christian Becker, Gudrun Nürnberg, Vincent Cantagrel, Joseph G. Gleeson, Delphine Gomez, Jean-Baptiste Michel, Sigmar Stricker, Tom H. Lindner, Peter Nürnberg, Kazuyuki Sugahara, Stefan Mundlos, Katrin Hoffmann
  • Bone and skin disorders caused by multiple mutations in the enzymes involved in the synthesis of chondroitin and dermatan sulfate
  • Suppression of the metastasis of Lewis lung carcinoma cells by regulating the expression of chondroitin sulfate E structure
  • A new type of Ehlers-Danlos syndrome caused by loss-of-function mutations of dermatan 4-O-sulfotransferase-1
    ○Shuji Mizumoto, Noriko Miyake, Tomoki Kosho, Shuhei Yamada, Kazuyuki Sugahara, and Naomichi Matsumoto
  • Loss-of-function mutations of dermatan 4-O-sulfotransferase-1 cause a new type of Ehlers-Danlos syndrome
    Shuji Mizumoto, Noriko Miyake, Tomoki Kosho, Shuhei Yamada, Kazuyuki Sugahara, and Naomichi Matsumoto
  • Spondyloepiphyseal dysplasia is caused by multiple mutations in the chondroitin 6-O-sulfotransferase-1 gene
    ○S. Mizumoto, M. H. van Roij, B. Tuysuz, T. Morgan, M. B. Tan-Sindhunata, H. Meijers-Heijboer, J.I. Verbeke, D. Markie, S. Mundlos, S. Turkmen, S. P. Robertson, S. Yamada, K. Sugahara
    The 25th International Carbohydrate Symposium (ICS2010)
  • Effects of the deficiency of chondroitin 4-O-sulfotransferase-1 on the sulfation of chondroitin sulfate-protein linkage region
  • Spondyloepiphyseal displasia is caused by multiple mutations in the chondroitin 6-O-sulfotransferase-1 gene
    ○Shuji Mizumoto, Mirjam H.H. van Roij, Beyhan Tuysuz, Shuhei Yamada, Tim Morgan, Ahmet Çelebi, M.B. Tan-Sindhunata, H. Meijers-Heijboer, J.I.L.M. Verbeke , David Markie, Stefan Mundlos, Seval Turkmen, Stephen P. Robertson, and Kazuyuki Sugahara
  • Omani type spondyloepiphyseal dysplasia with cardiac involvement caused by a new missense mutation in chondroitin 6-O-sulfotransferase-1
    Beyhan Tuysuz, ○Shuji Mizumoto, Kazuyuk, Ahmet Çelebi, Stefan Mundlos, Seval Turkmen
    Biochemistry and Molecular Biology 2008 Symposium
  • A novel mutation in human chondroitin 6-O-sulfotransferase-1
    ○Shuji Mizumoto, Mirjam H.H. van Roij, Shuhei Yamada, Tim Morgan, M.B. Tan-Sindhunata, H. Meijers-Heijboer, J.I.L.M. Verbeke , David Markie, Stephen P. Robertson, and Kazuyuki Sugahara
  • Occurrence of a non-sulfated chondroitin proteoglycan in the dried saliva of collocalia swiftlets (edible bird’s nest)
    Hiroki Nakagawa, Yoichiro Hama, Toshihisa Sumi, Su-Chen Li, Karol Maskos, Kittiwan Kalayanamitra, ○Shuji Mizumoto, Kazuyuki Sugahra, and Yu-The Li
  • Substrate specificities of three distinct chondroitin/dermatan 5-O-sulfotransferases in human and zebrafish
    ○Shuji Mizumoto, Naoki Kobayashi, Tadahisa Mikami, Naohide Kago, Hiroshi Kitagawa, Ayumi Miyake, Nobuyuki Itoh, Kazuyuki Sugahara
    US/Japan Glyco 2004
  • Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor
    ○Shuji Mizumoto、Tadahisa Mikami、Naohide Kago、Hiroshi Kitagawa、Kazuyuki Sugahara
    Pharmaceutical Sciences World Congress 2004

Other

  • Congenital Disorders Caused by Defects in Catabolism of Glycosaminoglycans
    Shuhei Yamada, Shuji Mizumoto
    Trends in Glycoscience and Glycotechnology
    FCCA
    32, 188, E127, E133
    Jul. 2020
  • Congenital Disorders Caused by Defects in Anabolism of Glycosaminoglycans
    Shuji Mizumoto, Shuhei Yamada
    Trends in Glycoscience and Glycotechnology
    FCCA
    32, 186, E45, E51
    Mar. 2020
  • Recent Advances in the Pathophysiology of Musculocontractural Ehlers-Danlos Syndrome
    Tomoki Kosho, Shuji Mizumoto, Takafumi Watanabe, Takahiro Yoshizawa, Noriko Miyake, and Shuhei Yamada
    Genes
    11, 1, 43
    Jan. 2020
  • Hereditary skeletal and skin disorders caused by defects in biosynthesis of chondroitin/dermatan sulfate, and molecular mechanism of pulmonary metastasis
    Shuji Mizumoto
    YAKUGAKU ZASSHI
    The Pharmaceutical Society of Japan
    139, 12, 1495, 1500
    Dec. 2019
  • Functional Analysis of Dermatan Sulfate and Chondroitin Sulfate
    Shuji Mizumoto
    Trends in Glycoscience and Glycotechnology
    31, 181, SE98, SE99
    Jul. 2019
  • Defects in Biosynthesis of Glycosaminoglycans Cause Hereditary Bone, Skin, Heart, Immune, and Neurological Disorders
    Shuji Mizumoto
    Trends in Glycoscience and Glycotechnology
    30, 174, E67, E89
    May 2018
  • Proteoglycan linkeropathies caused by defect in glycosaminoglycan-protein linker region
    Shuji Mizumoto
    Seikagaku
    The Japanese Biochemical Society
    89, 2, 259, 263
    Apr. 2017
  • Pathophysiological Significance of Dermatan Sulfate Proteoglycans Revealed by Human Genetic Disorders
    Shuji Mizumoto*, Tomoki Kosho, Shuhei Yamada, and Kazuyuki Sugahara* (*corresponding author)
    Pharmaceuticals
    10, 2, e34
    27 Mar. 2017
  • Mutations in biosynthetic enzymes for the protein linker region of chondroitin/dermatan/heparan sulfate cause skeletal and skin dysplasias
    *Shuji Mizumoto, Shuhei Yamada, and *Kazuyuki Sugahara (*corresponding author)
    BioMed Research International
    Hindawi Publishing Co.
    2015, 861752
    Oct. 2015
  • Molecular interactions between chondroitin–dermatan sulfate and growth factors/receptors/matrix proteins
    Shuji Mizumoto, Shuhei Yamada, Kazuyuki Sugahara
    Current Opinion in Structural Biology
    Elsevier Ltd.
    34, 35, 42
    09 Jul. 2015
  • Investigation of chondroitin sulfate /hyaluronan-degrading enzyme(s) in central nervous system
    Shuhei Yamada, Yuka Oiwa, Shuji Mizumoto, Ryoji Kojima, and Tadashi Nagamatsu
    Bulletin of Research Institute of Meijo University
    Meijo University
    20, 149, 152
    31 Mar. 2015
  • Expression of Receptor for Advanced Glycation End-products (RAGE) in Pichia pastoris
    Shuji Mizumoto, Shuhei Yamada, and Kazuyuki Sugahara
    Bulletin of Research Institute of Meijo University
    Meijo University
    20, 231, 234
    Mar. 2015
  • Human Genetic Disorders and Knockout Mice Deficient in Glycosaminoglycan
    *Shuji Mizumoto, Shuhei Yamada, and *Kazuyuki Sugahara (*corresponding author)
    BioMed Research International
    Hindawi Publishing Corporation
    2014, 495764
    13 Jul. 2014
  • Functional analysis of hyaluronidase-4 in various pathological conditions such as cancer
    Shuhei Yamada, Tomoyuki Kaneiwa Shuji Mizumoto, and Kazuyuki Sugahara
    Bulletin of Research Institute of Meijo University
    19, 113, 116
    31 Mar. 2014
  • Shuji Mizumoto
    45, 12, 1621, 1621
    Dec. 2013
  • Shuji Mizumoto
    26, 73, 73
    Aug. 2013
  • Glycosaminoglycans are functional ligands for Receptor for Advanced Glycation End-products (RAGE) in tumors
    Shuji Mizumoto and Kazuyuki Sugahara
    FEBS Journal
    280, 10, 2462, 2470
    May 2013
  • Human genetic disorders caused by defective genes encoding biosynthetic enzymes for sulfated glycosaminoglycans
    Shuji Mizumoto, Shiro Ikegawa, and Kazuyuki Sugahara
    Journal of Biological Chemistry
    288, 16, 10953, 10961
    Apr. 2013
  • Reduction of Chondroitin 4-O-Sulfotransferase-1 Expression Causes Costello Syndrome
    Shuji Mizumoto
    Trends in Glycoscience and Glycotechnology
    25, 142, 87, 89
    Mar. 2013
  • ISCSM2011 Chondroitin sulfate E-type structure at tumor cell surface is involved in experimental metastasis
    Kazuyuki SUGAHARA and Shuji MIZUMOTO
    Advances in Experimental Medicine and Biology "Biochemical Roles of Eukaryotic Cell Surface Macromolecules", (P. R. Sudhakaran and A. Surolia, eds)
    Springer
    749, 33, 45
    May 2012
  • A response to: Loss of dermatan-4-sulfotransferase 1 (D4ST1/CHST14) function represents the first dermatan sulfate biosynthesis defect, “ Dermatan sulfate-deficient adducted thumb-clubfoot syndrome”. Which name is appropriate, “Adducted thumb-clubfoot syndrome” or “Ehlers-Danlos syndrome”?
    Tomoki Kosho, Noriko Miyake, Shuji Mizumoto, Atsushi Hatamochi, Yoshimitsu Fukushima, Shuhei Yamada, Kazuyuki Sugahara, and Naomichi Matsumoto
    Human Mutation
    32, 12, 1507, 1509
    Dec. 2011
  • Disorder of Biosynthesis of Dermatan Sulfate Causes a New Type of Ehlers-Danlos Syndrome
    Shuji Mizumoto
    Trends in Glycoscience and Glycotechnology
    23, 132, 197, 199
    Jul. 2011
  • Roles of Dermatan Sulfate Epimerase
    Shuji Mizumoto
    Trends in Glycoscience and Glycotechnology
    22, 127, 256, 258
    Sep. 2010
  • Biosynthesis and roles in skin of glycosaminoglycans
    Taishi Hashiguchi, Shuji Mizumoto, Kazuyuki Sugahara
    Fragrance Journal
    38, 1, 18, 24
    Jan. 2010
  • Chondroitin Hydrolase in Caenorhabditis elegans
    Shuhei Yamada, Shuji Mizumoto, Kazuyuki Sugahara
    Trends in Glycoscience and Glycotechnology
    21, 119, 149, 162
    May 2009
  • Fine regulatory mechanism of glycosaminoglycan biosynthesis
    53, 12, 1448, 1455
    Aug. 2008
  • Recent advances in the structural study of functional chondroitin sulfate and dermatan sulfate in health and disease
    Christina Malavaki*, Shuji Mizumoto*, Nikos Karamanos, Kazuyuki Sugahara
    Connective Tissue Research
    49, 3, 133, 139
    May 2008
  • Regulation of the neuritogenesis by chondroitin sulfate/dermatan sulfate
    Shuji Mizumoto, Kazuyuki Sugahara
    25, 7, 990, 997
    Apr. 2007

License

  • 2007-291424
    2009-114147
    P2007-155
  • 2009-238490
    2011-084516


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